Endocrine Abstracts

Introduction: While severe GH deficiency (GHD) is a well-established feature of Sheehan’s syndrome (SS), the effects of GH deficiency in these patients has not been extensively investigated. In the present studyh we evaluated the cardiovascular risk in patients with SS.Methods: Twenty female with SS and well-treated with cortisone and thyroid hormones was included. Metabolic syndrome according to IDF-2005 criteria and insulin resistance estimated by...

Introduction: Schmidt’s syndrome also known as autoimmune polyglandular syndrome type 2 (APS type 2) is a rare endocrine disorder defined by the combined occurrence of Addison disease with autoimmune thyroid disease. The rarity of the condition and the atypical presentation of adrenal insufficiency and hypothyroidism often lead to misdiagnosis with life-threatening consequences for the patient. In this study we report an exhaustive monocentric analysis of 22 patients diag...

Introduction: The insulin tolerance test (ITT) is accepted as the gold-standard test in the evaluation of adrenal and GH axis in patients with pituitary disorders. Diagnostic criteria that requires a minimum increment in serum cortisol is considered invalid although individuals who have a lower basal serum cortisol concentration because of recent ACTH deficiency may be maximally stimulated by ITT and thus able to further increase cortisol secretion without reaching the cut-off...

Context: GH deficiencies could be associated with other pituitary insufficiencies. Our main objective is to assess othe pituitary secretion in short stature patients.Patients and methods: Twenty three patients (17 boys, 6 girls) were included in the study for exploration of short stature, after oral and informed consent of their parents, from January 2016 to June 2017 in the Department of Endocrinology of the University Hospital of Farhat Hached Sousse. ...

Introduction: Precocious puberty (PP) is the development of secondary sexual characteristics before the age of 8 years in girls and beforethe age of 9 years in boys. Central PP has an idiopathic origin in upto 95% of girls while in up to 50% of males. The diagnostic and the management of PP can beparticularly complex. Here we describe cases of two sisters having central PP with different presentation and evolution.Observations: First case: A 13-years-old...

IntroductionAcid sphingomyelinase-deficient Niemann–Pick disease (NPD) is a lysosomal lipid storage disorder. We report a new case of Hashimoto thyroiditis associated to primary adrenal insufficiency (PAI) likely of infiltrative process occurring in NPD type B patient.ObservationA 24-year-old Tunisian female patient was followed up in our endocrinology department for Hashimoto thyroiditis. Two years late...

IntroductionKlinfelter syndrome (SK) is the most common sex chromosome disorder. Affected males carry an additional × chromosome, which results in male hypogonadism, obesity and an insulin resistance field explaining the frequent association of KS and type 2 diabetes. However, cases of type 1 diabetes (T1D) in KS are rarely reported in the literature. We report a case.ObservationThis is a 31-year-old pat...

IntroductionTurner syndrome (TS) is among the most common chromosomal abnormalities in females, resulting from structural or numeric abnormalities in the X chromosome. Autoimmune disorders, especially thyroid diseases have a high prevalence among these patients. Usually Hashimoto’s thyroiditis (HT) is the most frequent one, whilst the association between this syndrome and Graves’ disease (GD) has been less often reported. Here we report a case ...

IntroductionAcromegaly is a rare disease, but serious in its complications. It is a multisystemic pathology also affecting the thyroid. The aim of our work is to study thyroid involvement in acromegaly.Patients and methodsThis is a retrospective study of acromegalic patients, in the endocrinology department of Sousse over a period of 20 years.ResultThese are 40 ac...

IntroductionWerner syndrome (WS) is a rare genetic disorder that displays clinical features suggestive of accelerated aging. Also known as adult progeria, it is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. Primary characteristics of this syndrome are progeroid changes of hair, bilateral cataract, atrophic skin, soft-tissue calcification, bird-like face, abnormal voice and many others features. Here we report 5 patients...